Azul de metileno
A dye and real drug for methemoglobin; cognitive/longevity hype doesn't turn internet pills into therapy.
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Quick summary
Methylene blue is an old compound with a modern label for methemoglobinemia. It's also being researched for mitochondria and neurodegeneration. Research/longevity catalog tablets do not automatically inherit the safety or dosage of the hospital IV, and there are serious interactions with serotonergic drugs.
Studied for
How it works
Redox: accepts/donates electrons in the respiratory chain at low doses (hormesis discussed); at other doses it's an oxidant. It inhibits MAO to some extent — the basis for serotonergic risk.
What the research says
ProvayBlue label. Experimental cognitive/mitochondrial literature — not established as a supplement. FDA/label warnings about MAOIs and SSRIs.
Evidence level
A for IV methemoglobinemia; C–D for oral nootropic
What's most reported
- Methemoglobinemia reversal (clinical)
- Expected urine/blue discoloration
- Community: focus/energy — anecdotal
Common side effects
Per label: hypertension, hemolysis (G6PD), serotonin syndrome with serotonergic drugs, fluid discoloration. Oral research: incomplete profile.
Combines / does not combine
Avoid with MAOIs, SSRIs, SNRIs, tramadol, etc. (serotonergic risk). Caution in G6PD deficiency.
Frequently asked questions
There is no approved longevity regimen; plus, the interactions are serious.
Not necessarily in purity, dose, or route.
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Educational content. Not medical advice or usage guidance. Research products are not approved drugs unless otherwise indicated.