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How it works

Mimics GLP-1, slowing stomach emptying, reducing hunger signals in the brain, and improving blood sugar control.

Most reported

• Less appetite and cravings
• Gradual sustained weight loss
• Better blood sugar control

Evidence level

Strong clinical backing — large human trials published in top journals. STEP-1 trial: 14.9% average weight loss over 68 weeks.

Common side effects

Nausea and digestive issues, especially when increasing dose. Start low and go up slowly.

Combines / avoids

Do not combine with another GLP-1 (Tirzepatide or Retatrutide).

Typical use

1 weekly subcutaneous injection, starting at 0.25 mg, increasing every 4 weeks.

How it works

Where semaglutide activates one pathway, tirzepatide activates two (GLP-1 + GIP), producing more results than a GLP-1 alone.

Most reported

• Notable weight loss
• Less hunger between meals
• Better blood sugar control

Evidence level

Strong clinical backing. SURMOUNT-1 trial: up to 22.5% weight loss at 72 weeks with 15 mg dose. Beat semaglutide head-to-head in SURMOUNT-5.

Common side effects

Nausea and digestive issues when increasing dose (mild to moderate).

Combines / avoids

Do not combine with another GLP-1 (Semaglutide or Retatrutide).

Typical use

1 weekly subcutaneous injection, starting at 2.5 mg, increasing every 4 weeks.

How it works

Activates three metabolic pathways at once; the glucagon component adds an effect on energy expenditure.

Most reported

• High weight loss in trials
• Strong appetite reduction

Evidence level

In human clinical trials (Phase 3); not yet approved.

Common side effects

Nausea and digestive issues; may slightly raise heart rate.

Combines / avoids

Do not combine with another GLP-1.

Typical use

1 weekly injection, starting at 2 mg and titrating every 4 weeks.

How it works

It is the "tail" of growth hormone — the part linked to mobilizing fat — without the part that affects blood sugar or growth.

Most reported

• Supports fat loss
• Without the typical GH side effects

Evidence level

Little human data; small studies.

Common side effects

Generally well tolerated; injection-site reaction.

Combines / avoids

Sometimes used alongside GH-boosting peptides.

Typical use

Daily dose of ~300 mcg.

How it works

Studied for promoting new blood vessel formation and modulating inflammation, which would help repair damaged tissues.

Most reported

• Better tendon and joint recovery
• Fewer digestive issues
• Faster recovery after training

Evidence level

Mostly animal studies; no large human trials.

Common side effects

Generally well tolerated; occasionally mild nausea, dizziness, or injection-site reaction.

Combines / avoids

Pairs well with TB-500 for recovery.

Typical use

4-6 week cycles, low daily dose (250-500 mcg).

How it works

Helps repair cells migrate to the injured area and promotes formation of new blood vessels.

Most reported

• Muscle-injury recovery
• More flexibility
• Less inflammation

Evidence level

Mostly preclinical; little human data.

Common side effects

Injection-site reaction; occasionally passing fatigue or dizziness.

Combines / avoids

Pairs with BPC-157. Banned in professional sport (WADA).

Typical use

2 times a week, dose of ~2-2.5 mg.

How it works

Aims to combine BPC-157's local repair with TB-500's more systemic action.

Most reported

• More complete overall recovery
• Tendon and muscle support

Evidence level

No human studies validating the combination as a whole.

Common side effects

Similar to its components; injection-site reaction.

Combines / avoids

Already a combination; avoid duplicating its components separately.

Typical use

Daily blend dose (~600-1000 mcg), in 4-6 week cycles.

How it works

Studied for calming inflammation signals inside the cell, with interest in gut and skin.

Most reported

• Less inflammation
• Digestive support
• Calmer skin

Evidence level

Mainly lab studies; little human data.

Common side effects

Well tolerated; injection-site reaction.

Combines / avoids

Usually comes inside the KLOW blend.

Typical use

Daily dose of ~500 mcg to 1 mg.

How it works

The copper and the peptide together stimulate collagen production and skin repair.

Most reported

• Firmer, better-looking skin
• Better wound healing
• Hair support

Evidence level

Good data via topical use (creams); the injectable route is less studied.

Common side effects

Injection-site reaction; copper accumulates, which is why it is cycled.

Combines / avoids

It's the base of the GLOW and KLOW blends.

Typical use

~5 days a week, dose of 1-2 mg, in cycles.

How it works

Combines collagen and skin support (GHK-Cu) with tissue repair (BPC-157 + TB-500).

Most reported

• More radiant skin ("glow" effect)
• Overall recovery

Evidence level

No human studies of the blend as a whole.

Common side effects

Those of its three components; injection-site reaction.

Combines / avoids

It's a blend; avoid duplicating GHK-Cu, BPC-157, or TB-500 separately.

Typical use

Fixed daily dose (~2.3 mg), in 4-week cycles.

How it works

Adds KPV's anti-inflammatory effect on top of the GLOW trio.

Most reported

• Skin and recovery, plus KPV's anti-inflammatory support

Evidence level

No human studies of the blend as a whole.

Common side effects

Those of its four components; injection-site reaction.

Combines / avoids

It's a blend; cycled because of the copper in GHK-Cu.

Typical use

Fixed daily dose (~2.7 mg), in 4-6 week cycles.

How it works

Mimics ghrelin and activates the pituitary gland to release more of your own growth hormone.

Most reported

• Muscle-mass support
• Better recovery
• Increased appetite

Evidence level

Small studies and clinic experience; no large trials.

Common side effects

Fluid retention, hunger, tingling in the hands; can raise cortisol and prolactin.

Combines / avoids

Pairs with a GHRH (CJC-1295). Do not combine two GHRPs at once.

Typical use

1-2 times a day, ~200 mcg.

How it works

Same as GHRP-2, but with a much more marked hunger signal.

Most reported

• Strong appetite (useful in a bulk)
• Muscle support
• Recovery

Evidence level

Small studies and clinic experience.

Common side effects

Intense hunger, fluid retention, tingling; raises cortisol and prolactin.

Combines / avoids

Pairs with CJC-1295. Do not combine two GHRPs at once.

Typical use

1-2 times a day, ~200 mcg.

How it works

Triggers GH release without affecting cortisol or prolactin, so it has fewer side effects than older GHRPs.

Most reported

• Better sleep
• Recovery
• Fewer side effects than others in the group

Evidence level

Small studies; the most well-characterized of the group thanks to its selectivity.

Common side effects

Very clean — occasionally mild retention, tingling, or passing headache.

Combines / avoids

Classic combo with CJC-1295 (No DAC), in the same syringe.

Typical use

Once a day (night), ~200-300 mcg.

How it works

Delivers a short GH pulse similar to the natural one; that's why it's combined with Ipamorelin, which acts on a different pathway.

Most reported

• More natural GH pulses
• Recovery (especially with Ipamorelin)

Evidence level

Small studies and clinic experience.

Common side effects

Fluid retention, tingling in the hands, mild fatigue or headache.

Combines / avoids

With Ipamorelin. Saturates at ~100 mcg (more doesn't help).

Typical use

Once a day (night), 100 mcg, alongside Ipamorelin.

How it works

Binds to a blood protein to last for days, keeping GH continuously elevated.

Most reported

• Sustained GH elevation
• Convenience of weekly dosing

Evidence level

Small studies.

Common side effects

Like the No DAC version; the constant elevation can cause more fluid retention.

Combines / avoids

The constant elevation doesn't mimic the natural rhythm; some prefer the No DAC version.

Typical use

Once a week, ~1-2 mg.

How it works

Stimulates your own GH with a marked effect on deep abdominal fat.

Most reported

• Reduction of deep abdominal fat
• Better body composition

Evidence level

Clinical backing — approved, with Phase 3 trials.

Common side effects

Injection-site reaction, retention or joint stiffness, may raise blood sugar. Not for pregnancy.

Combines / avoids

Sometimes used with Ipamorelin. Approved for a specific use (HIV); other uses are off-label.

Typical use

Daily dose of ~2 mg, at night.

How it works

Mimics the natural signal that tells the pituitary to release GH, gradually.

Most reported

• Better sleep
• More energy
• Gradual recovery

Evidence level

Prior clinical use — was approved (Geref), now discontinued; moderate data exists.

Common side effects

Injection-site reaction (most common), mild retention, headache.

Combines / avoids

Alone or with a GHRP.

Typical use

Daily dose of ~200-300 mcg, at night.

How it works

Triggers a strong GH release, but the receptor gets used to it quickly.

Most reported

• Strong GH release
• Muscle support

Evidence level

Small studies.

Common side effects

Retention, tingling; raises cortisol and prolactin; desensitizes quickly.

Combines / avoids

Used in cycles because of desensitization. Not with another GHRP.

Typical use

1-2 times a day, ~100 mcg.

How it works

Studied for influencing neurotransmitters linked to anxiety, without the sedating effect of a classic anxiolytic.

Most reported

• Sense of calm
• Less anxiety
• No drowsiness

Evidence level

There are human studies, but almost all in Russia.

Common side effects

Well tolerated; occasionally nasal irritation (via spray).

Combines / avoids

Pairs well with Semax (calm + focus).

Typical use

Daily dose of ~250-300 mcg. Also used intranasally.

How it works

Studied for increasing factors that support neurons and improving brain signaling.

Most reported

• More focus and clarity
• Memory support

Evidence level

There are human studies, but almost all in Russia.

Common side effects

Well tolerated; nasal irritation (via spray).

Combines / avoids

With Selank. Take in the morning because it's activating.

Typical use

Daily dose of ~300 mcg, in the morning. Also intranasal.

How it works

Studied for activating an enzyme (telomerase) linked to cellular aging, and for regulating melatonin.

Most reported

• Better sleep
• Interest for its effect on cellular aging

Evidence level

Very limited human data; mostly Russian and animal studies.

Common side effects

Well tolerated; mild injection-site reaction.

Combines / avoids

Usually used alone, in short cycles with long breaks.

Typical use

10-20 day cycles (5 mg/day), 2-3 times a year.

How it works

Activates a cellular "switch" (AMPK), the same one exercise turns on, linked to energy use.

Most reported

• More energy
• Metabolism support
• Better endurance

Evidence level

Very young (discovered in 2015); little human data.

Common side effects

Injection-site reaction; little long-term info. Banned in sport (WADA).

Combines / avoids

Used alone, in cycles.

Typical use

~5 mg every 5 days, in ~20-day cycles.

How it works

It's a "fuel" cells use to produce energy; its levels drop with age.

Most reported

• More energy
• Mental clarity
• Sense of recovery

Evidence level

Used in clinics; human evidence is mixed.

Common side effects

The injection can burn (that's why it's slow and diluted), flushing, nausea if given quickly.

Combines / avoids

Used alone. Once reconstituted it degrades quickly (use within ~2 weeks).

Typical use

Dose of 50-100 mg, 5 days a week, via slow injection.

How it works

Works on the central nervous system on desire, not on blood flow like erection pills.

Most reported

• Increased sexual desire
• Effect in both men and women

Evidence level

Clinical backing — approved (Vyleesi), with Phase 3 trials.

Common side effects

Nausea (very common), facial flushing, headache, passing blood-pressure rise; skin darkening with repeated use.

Combines / avoids

Used alone, as needed. Approved for premenopausal women; in men it's off-label.

Typical use

1 to 1.75 mg about 45 min before, max once a day.