Melanotan-1
α-MSH analog more selective for MC1R than MT-2; the real drug is an implant, not an internet vial.
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Quick summary
Melanotan-1 is the popular name for the analog [Nle⁴, D-Phe⁷]-α-MSH, the chemical basis of afamelanotide. Unlike Melanotan-2, it is more oriented towards MC1R (pigmentation) with fewer central libido effects. The pharmaceutical product Scenesse is a controlled-release subcutaneous implant for adults with EPP. The powders/vials sold as “MT-1 research” do not undergo that control.
Studied for
How it works
MC1R agonism in melanocytes → increase in eumelanin. In EPP, the clinical objective is to increase pain-free time under light, not the “aesthetic tan” from forums.
What the research says
Approved: FDA 2019 and EMA — Scenesse for EPP (trials CUV039, CUV029, etc.). Research vials: no demonstrated equivalence with the implant; unknown dose, purity, and impurities. Reviews on unregulated α-MSH analogs also apply to illegal MT-1.
Evidence level
A for Scenesse/EPP; D for “MT-1” research vials
What's most reported
- With Scenesse (label): nausea, fatigue, implant site reactions, expected pigmentary darkening
- With illegal vials: total uncertainty + preparation risks
Common side effects
Profile known only for the approved product in its population. Research vials: unknown; general warnings for melanotans apply (changes in nevi, impurities).
Combines / does not combine
Do not mix with MT-2 or other melanocortin agonists. Dermatological surveillance if there are numerous nevi.
Avoid
- Melanotan-2Do not mix with MT-2 or other melanocortin agonists.
Frequently asked questions
No. They are different products in form, quality control, and indication.
The approved drug has safety data in EPP. The illegal vial does not inherit that safety. Compared to MT-2, the MT-1 type analog usually has fewer central effects, but that does not make the internet product safe.
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Educational content. Not medical advice or usage guidelines. Research products are not approved medications unless otherwise indicated.