5-Amino-1MQ
NNMT inhibitor with promising data in obese mice… and zero published human trials.
Updated:
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Quick summary
5-Amino-1MQ (5-amino-1-methylquinolinium) is not a peptide: it is a small molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), which consumes nicotinamide and SAM. The hypothesis: by blocking NNMT, intracellular NAD+ / SAM increase and lipogenesis decreases. In mice with diet-induced obesity, it reduces fat gain and improves metabolic markers. There are no published safety or efficacy studies in humans.
Studied for
How it works
Selective inhibition of NNMT → less 1-methylnicotinamide; more availability of precursors for NAD+ and methylation. In adipocytes: less lipogenesis. In DIO mice: less fat mass without (in some papers) necessarily reducing intake.
What the research says
Animals: Neelakantan et al. 2018 (PMC5826726) — NNMT inhibitors reverse diet-induced obesity in mice. Babula et al. 2024 (Diabetes Obes Metab) — 28 days, improved glucose tolerance and liver. Humans: no RCTs, no indexed case series, no clear registered trials of the compound as such. Hype vs. reality: the “fat loss peptide” marketing is misleading in two ways: it's not a peptide and there is no human data.
Evidence level
D — preclinical only (mice/cells)
What's most reported
- In mice: less fat, improved glucose/liver
- In forums: weight loss (anecdotal; not evidence)
Common side effects
Unknown in humans. In mouse papers, good short-term tolerance is described within the study's context — do not extrapolate.
Combines / does not combine
Stacks with “NAD boosters” or exercise mimetics are speculative. Interactions with methylation / cancer (NNMT is also studied in oncology) are not clarified for wellness use.
Frequently asked questions
No. It is a small molecule quinolinium.
None published as of the editorial closing of this file.
In obese mice, yes, there are signals. In humans, unknown.
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Educational content. Not medical advice or usage guidelines. Research products are not approved medications unless otherwise indicated.