SLU-PP-332
Exercise mimetic via ERR in mice; no public clinical history in humans yet.
Updated:
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Quick summary
SLU-PP-332 is a synthetic agonist of the estrogen-related receptors (ERR). In mice, it induces a gene program similar to aerobic exercise and improves exercise capacity / metabolic parameters. It is not a mitochondrial uncoupler (that would be BAM15 or others).
Studied for
How it works
Activation of ERRα (mainly) → genes for fatty acid oxidation, mitochondrial biogenesis, and acute exercise response in muscle.
What the research says
PubMed 36988910 (ACS Chem Biol 2023). PMC10801787 — ERR agonist and metabolic syndrome in models. No human RCTs.
Evidence level
D
What's most reported
- Mice: more endurance / better metabolism
- Forums: “cardio in a pill” — hype
Common side effects
Unknown in humans.
Combines / does not combine
Do not confuse or blindly stack with AICAR or BAM15 (different mechanisms; unknown toxicity).
Frequently asked questions
There is no human evidence.
No. AICAR → AMPK/ZMP; SLU-PP-332 → ERR.
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Educational content. Not medical advice or usage guidelines. Research products are not approved medications unless otherwise indicated.